Stsate Treasurer Richard Mourdock (R) defeated six-term Senator Richard Lugar in the Indiana primary.
Via NBC Politics:
Republican foreign policy elder statesman Sen. Richard Lugar, 80, first elected to the Senate in 1976, was defeated in the Indiana primary Tuesday by state Treasurer Richard Mourdock, who was backed by conservatives ranging from the National Rifle Association to local Tea Party activists to the Washington-based fiscal conservative group the Club for Growth.
Mourdock scored a landslide victory, winning more than 60 percent of the vote with almost all precincts reporting.
Legal Insurrection provides some tweet reactions to the Lugar loss.
Weasel Zippers sums it up "Obama’s favorite Republican — Dick Lugar — is history, and the Tea Party lives."